Behavioral Tests on Murine Models with Gelsemium sempervirens
نویسندگان
چکیده
منابع مشابه
Gelsemium sempervirens and Animal Behavioral Models
In traditional Materia Medica, Gelsemium sempervirens (G. sempervirens) is described as a remedy for a variety of anxiety-like psychological and behavioral symptoms, however consistent evidence of its efficacy is lacking. In our recent experimental studies (Bellavite et al., 2009; Magnani et al., 2010), groups of CD1 mice were treated with highly diluted solutions of G. sempervirens, or with co...
متن کاملGelsemine and Gelsemium sempervirens L. Extracts in Animal Behavioral Test: Comments and Related Biases
due to Gelsemium noxious compounds if more selective compounds can be identified. Centesimal (C) dilutions of G. sempervirens (4C, 5C, 7C, 9C, and 30C) appeared able to change significantly mouse behavioral effects as assessed in the open-field (OF) and light–dark (LD) tests in blind and randomized fashion (Magnani et al., 2010) but effects in the elevated plus-maze, an assay considered to be i...
متن کاملPharmacological Evaluation of Gelsemium sempervirens roots for CNS Depressant Activity
The aim of the present study was to investigate CNS depressant activity of methanolic extract of Gelsemium sempervirens roots. G. sempervirens Ait (Loganiaceae) is used traditionally in the treatment of migraine, neuralgia, rheumatism, restlessness, mental irritability, insomnia and ovarian and uterine pain. The plant was found to contain alkaloids gelsemine, gelseminine, gelsemoidine and gelse...
متن کاملExperimental neuropharmacology of Gelsemium sempervirens: Recent advances and debated issues
Gelsemium sempervirens L. (Gelsemium) is traditionally used for its anxiolytic-like properties and its action mechanism in laboratory models are under scrutiny. Evidence from rodent models was reported suggesting the existence of a high sensitivity of central nervous system to anxiolytic power of Gelsemium extracts and Homeopathic dilutions. In vitro investigation of extremely low doses of this...
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ژورنال
عنوان ژورنال: Clinical and Experimental Pharmacology
سال: 2012
ISSN: 2161-1459
DOI: 10.4172/2161-1459.1000101